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利用单克隆抗－ＤＮＡ抗体检测了３９名狼疮性肾炎（ＬＮ）患者不同的时期内不同类型的血清ＤＮＡ－抗－ＤＮＡ免疫复合物（抗ＤＮＡＩＣ），其中２４例做了肾活检。结果显示：活动期ＬＮ患者血清抗－ＤＮＡＩＣ的类型分布与患者的肾脏病理类型有一定的关系，有助于推测ＬＮ肾组织病理类型，ＩｇＧ型的抗单链ＤＮＡＩＣ（抗－ｓｓＤＮＡ－ＩｇＧ）与２４ｈ尿蛋白定量呈正相关。进一步说明抗－ＤＮＡＩＣ在ＬＮ的发病机理中有较重要的作用。
Thirty-nine patients with lupus nephritis (LN) were tested for different types of serum DNA-anti-DNA immune complexes (anti-DNAIC) at different times using monoclonal anti-DNA antibodies. Twenty-four of these patients underwent renal biopsy. The results showed that the type of anti-DNAIC in patients with active LN had some relationship with the pathological type of kidney, which was helpful to infer the histopathological types of LN, the anti-ssDNA DNA IgG (anti-ssDNA-IgG) 24h urinary protein was positively correlated. Further illustrate anti-DNAIC in the pathogenesis of LN has a more important role.