论文部分内容阅读
目的：观察肝结散对ＣＣｌ４诱导的小鼠肝纤维化损害的预防作用。方法：以小剂量ＣＣｌ４橄榄油溶液长期腹腔注射造成小鼠慢性肝损伤性纤维化模型，同时预先以不同剂量肝结散口服给药，与秋水仙碱对照，观察肝组织形态结构及其胶原代谢等的变化。结果：肝结散高、低剂量组小鼠血谷丙转氨酶活性（ＡＬＴ１３０．４４±４２．８，１４５．３±３８．９）、ＬＰＯ（６．４２±０．６４，６．７４±０．７１）、ＰＣⅢ（１４５９．７±１７４．８，１４８５．４６±１６３．４）、ＨＡ（１７６１．３５±１５１．３６，１８１４．２８±１７０．３１）和肝纤维化积分（１．３１±０．８４，１．４２±０．７７）均明显低于对照组（分别为ＡＬＴ２０１．８±７８．５，ＬＰＯ８．７０±０．７２，ＰＣⅢ１９５６．８８±２０１．７１，ＨＡ２３３９．６４±２０９．８３，纤维化积分１．９６±１．０６），而白蛋白含量（３６．１±２．５，３４．６±２．７）、ＳＯＤ（１９．３８±４．２１，１８．８３±３．９０）、ＧＳＨ（４８．５２±３．６７，４６．６７±３．４２）均明显高于对照组（分别为白蛋白含量３０．４±５．６，ＳＯＤ１２．７５±２．７０，ＧＳＨ４０．００±２．６５）。结论：肝结散?
OBJECTIVE: To observe the preventive effect of Ganjiejie powder on liver fibrosis damage induced by CCl4 in mice. METHODS: Chronic liver injury fibrosis model was induced by intraperitoneal injection of small doses of CCl4 olive oil solution. At the same time, oral administration of different doses of Ganzhisan was used. Compared with colchicine, the morphological structure and collagen metabolism of liver tissue were observed. Changes such as. Results: The activity of alanine aminotransferase (ALT130.44±42.8, 145.3±38.9) and LPO (6.42±0.64, 6.74±0) in the high-dose and low-dose hepatic groups .71), PCIII (1459.7±174.8, 1484.46±163.4), HA (1761.35±151.36, 1814.28±170.31), and liver fibrosis score (1.31 (± 0.84, 1.42 ± 0.77) were significantly lower than the control group (ALT 201.8±78.5, LPO8.70±0.72, PCIII1956.88±201.71, HA2339.64±, respectively) 209.83, Fibrosis score 1.96±1.06), albumin content (36.1±2.5, 34.6±2.7), SOD (19.38±4.21, 18. 83±3.90), GSH (48.52±3.67, 46.67±3.42) are all obvious In the control group (albumin content of 30.4 ± 5.6, SOD12.75 ± 2.70, GSH40.00 ± 2.65). Conclusion: Liver dissociation?