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目的:通过对比试验的方式分析干扰素联合炎琥宁对小儿手足口病的治疗效果。方法:对某医院自2014年1月至2015年2月所收治的80例手足口病患儿进行编号,随机分成对照组和研究组,各40例,在对症治疗和一般治疗的基础上,给予对照组患儿应用利巴韦林抗病毒治疗,研究组应用干扰素联合炎琥宁进行治疗,连续治疗5天后,对比两组患儿的治疗效果。结果:研究组患儿的退热时间、手足口臀部疱疹消退时间、住院治疗时间等均明显低于对照组,两组患儿间差异明显具有统计学意义(P﹤0.05);研究组患儿痊愈30例,有效8例,无效2例,治疗总体有效率95%;对照组患儿痊愈10例,有效17例,无效13例,治疗总体有效率为67.5%。结论:干扰素联合炎琥宁治疗小儿手足口病见效快、治愈率高,是小儿手足口病治疗的一种理想用药方法,值得临床广泛应用。
OBJECTIVE: To analyze the therapeutic effect of interferon combined with metronidazole on children’s hand-foot-mouth disease through comparative test. Methods: A total of 80 HFMD children admitted to a hospital from January 2014 to February 2015 were randomly assigned to control group and study group (n = 40). On the basis of symptomatic treatment and general treatment, The patients in the control group were treated with ribavirin antiviral therapy. The study group was treated with interferon combined with metronidazole. Five days after continuous treatment, the therapeutic effect of two groups of children was compared. Results: The antipyretic time, the time of herpes and back of the hand, foot and mouth, hospitalization time in the study group were significantly lower than those in the control group, with significant difference between the two groups (P <0.05) In the control group, 10 cases were cured, 17 cases were effective, 13 cases were ineffective, and the overall effective rate was 67.5%. Conclusion: The combination of interferon and mesylate can treat children with hand-foot-mouth disease more quickly and with higher cure rate. It is an ideal medicine for the treatment of hand-foot-mouth disease in children and should be widely used clinically.