目的:探讨父亲单方为乙肝病毒(HBV)感染者对子代的影响。方法:对父亲HBsAg阳性,母亲血清HBVM及HBVDNA均为阴性的306个家庭进行父亲血清HBeAg阳性状态、父亲血清HBV-DNA病毒载量、父亲精液HBV-DNA载量及新生儿脐带血HBV-DNA进行临床观察。结果:父亲肝功能异常发生率为7.5%;新生儿HBV感染率为21.6%(66/306);病例组中父亲为HBeAg阳性者达81.8%、血液HBV DNA阳性者达100%、精液HBV DNA阳性者达54.2%,分别是阴性者中发生HBV父婴垂直传播的8.7倍、2.1倍和34.3倍。结论:临床观察结果表明,孕前保健中务必将准父亲的血清HBeAg、HBVDNA、精液HBV DNA列入男性HBsAg阳性者的检测常规,对阳性者进行必要的系统有效的抗病毒治疗将对防范乙肝父婴垂直传播起积极和有效的作用。 Objective: To investigate the impact of unilateral father’s hepatitis B virus (HBV) infection on offspring. Methods: Thirty-six families with negative HBsAg, HBVM and HBVDNA were enrolled in this study. Serum HBeAg positive status, father’s serum HBV-DNA viral load, father’s seminal HBV DNA load and neonatal cord blood HBV-DNA Clinical observation. Results: The incidence of abnormal liver function was 7.5% in father and 21.6% (66/306) in newborns. In the case group, 81.8% were HBeAg positive and 100% were HBV DNA. Positive 54.2%, respectively, were negative occurred in HBV vertical transmission of fathers and infants, 8.7 times, 2.1 times and 34.3 times. Conclusions: The results of clinical observation indicate that pre-pregnancy health care must be the prospective father’s serum HBeAg, HBVDNA, semen HBV DNA included in the test of male HBsAg-positive, the positive for the necessary systematic and effective antiviral therapy will prevent hepatitis B The vertical transmission of infants plays an active and effective role.