本文采用我国最早研制的一种口服二巯基类广谱重金属解毒剂二巯基丁二酸(DMSA)治疗肝豆状核变性(HLD)20例。总有效率为80％,显效率为45％,该药对年龄小、病情轻、脑型及精神障碍型患者疗效较好,且无严重副反应。实验结果表明,HLD患者胆汁铜含量明显低于非HLD。DMSA除可促进尿铜排泄外,尚有显著的促进胆囊排铜保锌的作用。肯定了DMSA对HLD的治疗有效性和低毒性。 In this paper, 20 cases of hepatolenticular degeneration (HLD) were treated with dimercaptosuccinic acid (DMSA), an oral dithiol broad-spectrum heavy metal antidote first developed in China. The total effective rate was 80%, markedly effective rate was 45%, the drug for younger, mild, brain and mental disorders in patients with better efficacy, and no serious side effects. Experimental results show that, HLD patients with bile copper content was significantly lower than non-HLD. In addition to DMSA can promote urinary copper excretion, there are significant to promote gallbladder copper zinc role. Confirms the efficacy and low toxicity of DMSA for HLD.