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早产儿出生后自身调控大脑血运失常可造成出血或缺血灶。处于窘迫状态下的新生儿大脑血运被动地受血压影响,脑血流量就可能过多或不足。高碳酸血症是颅内出血的一个危险因素,常需机械通气,使PaCO_2保持在正常范围,但是机械通气伴发的合并症例如气胸,也使大脑发生病态而且预后欠佳。健康的新生儿出生后在几小时内即可调整PaCO_2,使高碳酸状态变成正常。而早产儿出生后的短时间内,自主呼吸对脑血流(CBF)调整的影响,目前报道不多。为此作者选择18例出生后即有自主呼吸的早产儿,在出生后的2～3小时内,血压和PaCO_2自动变化时测定CBF的变化。
Premature babies born after their own regulation of cerebral blood supply disorders can cause bleeding or ischemic foci. Neonatal cerebral blood flow in a distressed state is passively affected by blood pressure, and cerebral blood flow may be excessive or insufficient. Hypercapnia is a risk factor for intracranial hemorrhage and often requires mechanical ventilation to keep PaCO 2 in the normal range, but complications associated with mechanical ventilation such as pneumothorax also make the brain morbid and poor prognosis. Healthy newborn babies can adjust PaCO_2 within hours to make the hypercapnic state normal. The short-term after birth, short-term, spontaneous breathing on the impact of cerebral blood flow (CBF) adjustment, is currently little reported. For this reason, the authors selected 18 premature infants with spontaneous breathing after birth and determined the change of CBF when blood pressure and PaCO 2 were automatically changed within 2 to 3 hours after birth.