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目的 :探讨CTn -I对急性心肌梗死 (AMI)诊断的价值。方法 :采集AMI患者 3 5例、不稳定性心绞痛 (UAP) 45例和健康者 3 2例静脉血 ,测定CTn -I、CK -MB。结果 :AMI患者入院时CTn -I、CK -MB的阳性率分别为 68 6%、5 9 2 %。CK -MB在UAP组仍有较高阳性率 ,而CTn -I在UAP组阳性率很低。CTn -I在AMI发生 4h左右可显著升高 ,8～ 16h达最高峰 ,5～ 6天仍高于临界 ;CK -MB在AMI发生 4～ 8小时显著升高 ,16～ 2 4h达最高峰 ,2～ 3天降至正常。结论 :CTn -I与CK -MB对AMI早期诊断价值基本相同 ,CTn -I具有更宽的诊断时间及高度的特异性 ,可作为AMI的首选诊断指标
Objective: To investigate the value of CTn -I in the diagnosis of acute myocardial infarction (AMI). Methods: Thirty five AMI patients, 45 UAP patients and 32 healthy volunteers were enrolled in this study. CTn-I and CK-MB were measured. Results: The positive rates of CTn-I and CK-MB in patients with AMI were 68.6% and 59.2% respectively. CK-MB in the UAP group is still a high positive rate, while CTn-I in the UAP group, the positive rate is very low. The level of CTn-I in AMI increased significantly at 4h, reached the peak at 8 ~ 16h, remained above the critical level at 5 ~ 6d; CK-MB increased significantly at 4 ~ 8h after AMI and peak at 16 ~ 24h , 2 to 3 days to normal. Conclusion: The value of CTn-I and CK-MB in the early diagnosis of AMI is basically the same, CTn-I has a wider diagnosis time and a high specificity, which can be used as the first choice of diagnosis of AMI