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目的:初步探讨阿司匹林对多囊卵巢综合征(PCOS)患者临床妊娠率的影响。方法:选择门诊确诊的PCOS患者90例及健康育龄妇女40例(对照组),监测体质量指数(BMI)、超敏C反应蛋白(CRP)及相关性激素。将PCOS患者随机分为氯米芬组,单用氯米芬促排卵治疗(n=40)和阿司匹林联合氯米芬组,先使用阿司匹林治疗3个月后,再联合氯米芬促排卵治疗(n=50)。检测用药治疗3个月前、后的BMI、CRP及相关性激素等指标。检测PCOS组促排卵治疗后hCG注射日子宫内膜厚度,并计算各组卵泡黄素化未破裂综合征(LUFS)发生率与临床妊娠率。结果:PCOS患者CRP水平明显高于对照组(P<0.05);PCOS患者经阿司匹林治疗后CRP水平明显下降(P<0.05);氯米芬组与阿司匹林联合氯米芬组的临床妊娠率分别为12.5%和31.9%(P<0.05)。结论:阿司匹林可以降低PCOS患者CRP水平、改善性激素水平异常、降低LUFS的发生率等,从而提高临床妊娠率。
Objective: To investigate the effect of aspirin on clinical pregnancy rate in patients with polycystic ovary syndrome (PCOS). Methods: 90 outpatients with PCOS and 40 healthy women of childbearing age (control group) were selected. Body mass index (BMI), hypersensitive C-reactive protein (CRP) and related hormones were monitored. PCOS patients were randomly divided into clomiphene citrate group, clomiphene alone ovulation induction therapy (n = 40) and aspirin combined with clomiphene citrate group, first with aspirin for 3 months, combined with clomiphene and ovulation induction therapy n = 50). Test medication for 3 months before and after the BMI, CRP and other related hormones and other indicators. The thickness of endometrium on hCG injection day after ovulation induction in PCOS group was detected, and the incidence of luteinized unruptured lutea (LUFS) and clinical pregnancy rate were calculated. Results: The CRP level in PCOS patients was significantly higher than that in the control group (P <0.05). The CRP levels in patients with PCOS after aspirin treatment were significantly decreased (P <0.05). The clinical pregnancy rates in clomiphene citrate group and aspirin group were 12.5% and 31.9% (P <0.05). Conclusion: Aspirin can reduce the CRP level in patients with PCOS, improve the abnormal sex hormone levels, reduce the incidence of LUFS and so on, so as to improve the clinical pregnancy rate.