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AIM:To evaluate the relationship of Helicobacter pyloriinfection to reflux esophagitis (RE),Barrett’s esophagus (BE)and gastric intestinal metaplasia (IM).METHODS:RE,BE and gastric IM were determined by upperendoscopy.Patients were divided into 2 groups;those withsquamocolumnar junction (SCJ) beyond gastroesophagealjunction (GFJ)≥3cm (group A),and those with SCJ beyondGEJ<3 cm (group B).Biopsy specimens were obtainedendoscopically from just below the SCJ,gastric antrum alongthe greater and lesser curvature.Pathological changes andH pylori infection were determined by HE staining,Alcianblue staining and Giemsa staining.RESULTS:The prevalence of H pylori infection was 46.93%.There was no difference in the prevalence between malesand females.The prevalence of H pylori infection decreasedstepwise significantly from RE grade Ⅰ to Ⅲ.There was nodifference in the prevalence between the two groups,andbetween long-segment and short-segment BE.In distalstomach,prevalence of H pylori infection was significantlyhigher in patients with IM than those without IM.CONCLUSION:There is a protective role of H pylori infectionto GERD.There may be no relationship between H pyloriinfection of stomach and BE.H pylori infection is associatedwith the development of IM in the distal stomach.
AIM: To evaluate the relationship of Helicobacter pylori infection to reflux esophagitis (RE), Barrett’s esophagus (BE) and gastric intestinal metaplasia (IM). METHODS: RE, BE and gastric IM were determined by uppereoscopy. Patients were divided into 2 groups; those withsquamocolumnar junction (SCJ) beyond gastroesophageal junction (GFJ) ≥3 cm (group A), and those with SCJ beyond GEJ <3 cm (group B) .Biopsy specimens were obtainedendoscopically from just below the SCJ, gastric antrum along the greater and lesser curvature. Pathological changes and H pylori infection were determined by HE staining, Alcianblue staining and Giemsa staining. RESULTS: The prevalence of H pylori infection was 46.93%. There was no difference in the prevalence between males and females. prevalence of H pylori infection decreased stepwise significantly from RE grade I to III. There was nodifference in the prevalence between the two groups, and between long-segment and short-segment BE. In distal metastomach, prevalence of H pylori infect ion was significantlyhigher in patients with IM than those without IM.CONCLUSION: There is a protective role of H pylori infectionto GERD. There may be no relationship between H pyloriinfection of stomach and BE.H pylori infection is associated with the development of IM in the distal stomach.