膀胱癌是泌尿系第2大肿瘤,在美国每年新诊断病例达57400,死亡人数达到12500[1]。膀胱癌的早期诊断可以改善预后,在其恶化为侵袭肌肉型之前确定诊断,可以降低膀胱切除的概率。膀胱癌的诊断方法包括膀胱镜检查、放射成像和尿液细胞学检查等[2]。尽管膀胱镜检查精确,但该法系侵入 Bladder cancer is the second largest urological tumor in the United States each year 57200 new cases were diagnosed, the death toll reached 12500 [1]. Early diagnosis of bladder cancer can improve the prognosis, confirm the diagnosis before it deteriorates to invade muscle type, and can reduce the probability of cystectomy. Bladder cancer diagnosis methods include cystoscopy, radiography and urine cytology [2]. Although cystoscopy is accurate, the law invades