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目的了解沿海地区中老年人高尿酸血症(hyperuricemia,HUA)与年龄、血脂、血压等危险因素的相关性。方法收集在内科门诊就诊的1 236例中老年高尿酸血症患者。实验室检测其尿酸(UA)、甘油三酯(TG)、同型半胱氨酸(Hcy)、游离脂肪酸(FFA)等水平,并统计年龄、性别、身体质量指数(BMI)、血压等指标,用Logistic回归分析高尿酸血症伴心血管疾病(CVD)的危险因素,研究高尿酸血症与各因素之间的相关性。结果高尿酸血症伴CVD患者与高尿酸血症不伴CVD患者在年龄、性别、血压、吸烟、饮酒、Hcy水平上相比较,差异有统计学意义(P<0.05)。Logistic回归结果显示,年龄、高血压、吸烟、饮酒、高Hcy水平等10个因素是高尿酸血症患者伴发CVD的危险因素。结论沿海地区高尿酸血症以男性中老年人为主。年龄、高血压、高血脂、高Hcy水平等均与高尿酸血症有关联。长期饮酒、吸烟是高尿酸血症伴CVD的危险因素。
Objective To understand the relationship between hyperuricemia (HUA) and age, blood lipid, blood pressure and other risk factors in the elderly in the coastal areas. Methods A total of 1 236 middle-aged and elderly patients with hyperuricemia were collected in internal medicine clinic. The levels of uric acid (UA), triglyceride (TG), homocysteine (Hcy) and free fatty acid (FFA) in the laboratory were measured and the indexes such as age, gender, body mass index (BMI) Logistic regression analysis of hyperuricemia with cardiovascular disease (CVD) risk factors to study the correlation between hyperuricemia and various factors. Results There were significant differences in age, sex, blood pressure, smoking, drinking, Hcy between patients with hyperuricemia and CVD without hyperuricemia and without CVD (P <0.05). Logistic regression analysis showed that 10 factors such as age, hypertension, smoking, alcohol consumption and high Hcy levels were risk factors of hyperuricemia associated with CVD. Conclusion The prevalence of hyperuricemia in the coastal areas is mainly in the middle-aged and elderly men. Age, hypertension, hyperlipidemia, high Hcy levels are associated with hyperuricemia. Long-term drinking, smoking is a risk factor for hyperuricemia with CVD.