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用ＰａｒｍａｃｉａＣＡＰ方法测定了２５９例健康人和１０３例慢性哮喘活动的患者血清嗜酸细胞阳离子蛋白（ＥＣＰ）水平，并分析其与痰嗜酸细胞计数、血清特异性ＩｇＥ之间的关系。结果显示：①正常个体血清ＥＣＰ水平的几何均数是４．７１μｇ／Ｌ，９５％的百分位数是１２．２０μｇ／Ｌ。血清ＥＣＰ水平高于１３μｇ／Ｌ时提示嗜酸细胞活化。②活动性哮喘患者血清ＥＣＰ水平（８．７０±１３．４０）μｇ／Ｌ显著高于健康对照组（５．４１±２．３０）μｇ／Ｌ，（Ｐ＜０．０１），但其中７５％的患者血清ＥＣＰ值＜１３μｇ／Ｌ。哮喘患者血清ＥＣＰ与血清特异性ＩｇＥ（Ｐ＜０．０１）、痰嗜酸细胞计数（ｒ＝０．５１，Ｐ＜０．０５）之间有一定正相关。
Serum eosinophilic cationic protein (ECP) levels were measured in 259 healthy subjects and 103 patients with chronic asthma using the ParmaciaCAP method and their association with sputum eosinophil count and serum-specific IgE were also analyzed. The results showed that: (1) The geometric mean ECP level of normal individuals was 4.71 μg / L and the 95% percentile was 12.20 μg / L. Serum ECP levels above 13 μg / L indicate eosinophil activation. ② The level of serum ECP in patients with active asthma (8.70 ± 13.40 μg / L) was significantly higher than that in healthy controls (5.41 ± 2.30 μg / L, P <0.01), but 75 % Of patients with serum ECP value <13μg / L. There was a positive correlation between serum ECP and serum specific IgE (P <0.01) and sputum eosinophil count (r = 0.51, P <0.05) in asthmatic patients.