论文部分内容阅读
本文采用RIA法检测了32例自发性腹膜炎(SBP)、24例肝硬化腹水、28例肝癌合并腹水以及30例其它消化道恶性肿瘤患者腹水肿瘤坏死因子(TNF)浓度。结果:SBP组TNF浓度显著高于肝癌合并腹水、其它消化道恶性肿瘤和肝硬化腹水组(P<0.01或P<0.001)。另外,肝癌腹水和其它消化道恶性肿瘤组腹水中TNF浓度亦高于肝硬化腹水组(P<0.01)。8例SBP病情危重、死亡者TNF平均值(1.09±0.24ng/ml)高于24例存活者平均值(0.71土0.28ng/ml)(P<0.01)。治疗有效者,TNF下降(0.26±0.11ng/ml)。本组结果表明,腹水TNF浓度的检测有助于SBP的诊断及预后的估价。
In this paper, 32 patients with spontaneous peritonitis (SBP), 24 patients with cirrhosis of the liver, 28 patients with hepatocellular carcinoma combined with ascites and 30 patients with other gastrointestinal malignancies were assayed for tumor necrosis factor (TNF) concentration by RIA. Results: The TNF level in SBP group was significantly higher than that in hepatocellular carcinoma with ascites, other gastrointestinal malignancies and cirrhosis ascites group (P <0.01 or P <0.001). In addition, ascites in patients with hepatocellular carcinoma and other gastrointestinal malignancies also showed higher levels of TNF in ascites than in cirrhotic patients (P <0.01). Eight of the SBP patients were critically ill. The mean TNF level at death (1.09 ± 0.24 ng / ml) was higher than that of 24 survivors (0.71 ± 0.28 ng / ml) (P <0.01). Therapeutically effective, TNF decreased (0.26 ± 0.11ng / ml). This group of results show that the detection of ascites TNF concentration contribute to the diagnosis of SBP and prognosis of the valuation.