P1 6蛋白是抑癌基因P1 6的蛋白产物 ,是迄今为止所发现的第一个最直接抑制肿瘤发生的细胞固有成分。P1 6蛋白主要与CDK4结合而使之失活 ,CDK4的失活在很大程度上影响了cyclins CDKs复合物的活性 ,Rb蛋白的磷酸化也就受到了抑制 ,使细胞停滞于G1 期 ,不再向S期过渡而停止增殖 ,进入G0 期。据统计 ,75 %的癌细胞株中有P1 6基因缺失和突变 ,是一个重要的多肿瘤抑制基因。P1 6基因的失活与泌尿系肿瘤的发生存在密切的关系 The P1 6 protein, a protein product of the tumor suppressor gene P1 6, is the first cell-specific component found to date that most directly inhibits tumorigenesis. The P1 6 protein is mainly inactivated by binding to CDK4. The inactivation of CDK4 largely affects the activity of the cyclins CDKs complex, and the phosphorylation of Rb protein is also inhibited, resulting in cell arrest in the G1 phase, not Then to the S-phase transition and stop proliferation, into the G0 period. According to statistics, 75% of cancer cell lines have P1 6 gene deletion and mutation, which is an important multi-tumor suppressor gene. The inactivation of P1 6 gene is closely related to the occurrence of urological tumors