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目的观察乳腺癌CAF方案化疗联合应用磷酸肌酸(CP)在心肌保护方面的疗效。方法 60例乳腺癌患者随机分为观察组和对照组,每组各30例患者。观察组采用CAF+CP治疗,对照组单纯采用CAF治疗。观察两组患者治疗前后心电图、心肌酶谱和不良反应的改变情况。结果两组患者治疗前心电图、心肌酶水平和不良反应发生情况相似,差异无统计学意义(P>0.05);CAF方案治疗2个周期后两组患者心电图、心肌酶水平和不良反应发生情况存在明显差异,差异有统计学意义(P<0.05)。结论磷酸肌酸能够明显改善乳腺癌CAF方案化疗对心脏的损害,有效保护心肌。
Objective To observe the therapeutic effect of combined use of CAF regimen and creatine phosphate (CP) on myocardial protection in patients with breast cancer. Methods Sixty patients with breast cancer were randomly divided into observation group and control group, with 30 patients in each group. The observation group was treated with CAF + CP and the control group with CAF alone. The changes of ECG, myocardial enzymes and adverse reactions in two groups before and after treatment were observed. Results Before treatment, the levels of electrocardiogram, myocardial enzymes and adverse reactions were similar between the two groups (P> 0.05). After 2 cycles of CAF regimen, ECG and myocardial enzyme levels and adverse reactions in both groups existed Significant difference, the difference was statistically significant (P <0.05). Conclusion Creatine phosphate can significantly improve the cardiac damage caused by chemotherapy of breast cancer CAF regimen and effectively protect myocardium.