DDS综合征表现为发热、皮疹,甚至剥脱性皮炎、肝炎、淋巴腺病及淋巴细胞增多等,常发生在服用DDS六周内,如不早期治疗可致死。作者报告一例有对称性一过性四肢多关节炎的DDS综合征。患者男性,56岁,BT,用DDS100毫克/日、RFP600毫克/月。5周后突然高热、恶心、肌肉酸痛、关节痛、有轻度搔痒红斑、斑丘疹和鳞屑样皮疹;发热后一周尿呈淡黄色,四肢关节疼痛肿胀,体温102°F,黄疸,全身有红斑、斑丘疹及鳞屑皮疹,手掌足底大片脱皮。大腿、手臂麻风损害无改变;口腔粘膜散在红斑,两侧颈、腋下及腹股沟淋巴结肿大坚硬伴轻度触痛;两腕、肘、踝及膝关节肿胀、触痛,活动 DDS syndrome manifested as fever, rash, and even exfoliative dermatitis, hepatitis, lymphadenopathy and lymphocytosis, etc., often occur within six weeks after taking DDS, if not early treatment can be fatal. The authors report a case of symmetrical transient polyarthritis of the limbs DDS syndrome. Patient Male, 56 years old, BT, with DDS 100 mg / day, RFP 600 mg / month. 5 weeks after the sudden high fever, nausea, muscle soreness, joint pain, mild itching erythema, maculopapular rash and scale-like; fever a week after the urine was pale yellow, limb pain, joint swelling, body temperature 102 ° F, jaundice, systemic erythema , Rash and scales rash, palm plantar large peeling. Thigh, arm, leprosy lesions no change; oral mucosa scattered in the erythema, both sides of the neck, armpits and groin lymph nodes with mild tenderness; two wrist, elbow, ankle and knee joint swelling, tenderness, activity