ObjectiveTo study the clinical value of a new MRI compatible percutaneous bone biopsy system. MethodsTwenty-six patients with bone lesions MRI-guided biopsies underwent using a 0.23-T open MR system combined with an iPath-200 optical leading system. ResultsOf the 26 biopsies, 23 samples were sufficient for histologicalexamination and the histopathologic diagnoses were confirmed. In the high-riskareas like spine, the biopsies were successfully done in 11 patients. No procedural complications occurred. ConclusionPercutaneous biopsy of bone lesions performed under MRI-guidance in an iPath system was proved to be accurate and safe.