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在离体培养人细胞中,细小病毒对恶性转化的细胞有明显的抑制作用。正常人胎肾和胃细胞对细小病毒H-1呈抗性,但它们被理化致癌因子转化后,对细小病毒敏感。小鼠成纤维细胞C_3H10T1/2被~3H-TdR转化后对细小病毒H-1的敏感性进一步提高。另外,细小病毒对肿瘤细胞的抑制作用还与细胞的分化状态有关,低分化型胃癌细胞MKN45比分化型胃癌细胞MKN28对H-1的杀伤作用更敏感。
In isolated cultured human cells, parvoviruses have significant inhibitory effects on malignantly transformed cells. Normal human fetal kidneys and stomach cells are resistant to parvovirus H-1, but they are sensitive to parvovirus after being transformed by physiochemical carcinogens. The sensitivity of mouse fibroblast C_3H10T1/2 transformed by ~3H-TdR to parvovirus H-1 was further increased. In addition, the inhibitory effect of parvovirus on tumor cells is also related to the differentiation state of cells. MKN45 poorly differentiated gastric cancer cells, the scored MKN28 gastric cancer cells, are more sensitive to the killing effect of H-1.