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血管收缩药是治疗分泌性中耳炎和咽鼓管功能障碍的常用药,但至今尚未发表过临床对照研究证实其防治中耳炎的功效。作者们对40名有分泌性中耳炎病史且做过双侧鼓室插管的儿童采用双盲法随机分为两组:一组用0.05%盐酸羟间唑啉,一组用安慰剂作鼻腔喷雾以观察对咽鼓管功能的影响。患儿年龄5～15岁,男24人,女16人,在观察期间无过敏性或感染性鼻炎,中耳无积液。在两天内鼻腔喷药治疗3次,喷药前后每人随机选定一耳采用改良的吹张-抽吸法和强迫反应法(forced response test)测定咽鼓管功能。结果两组无显著差异,说明盐酸羟间唑啉对咽鼓管功能无影响。但本文观察对象限于有严重咽鼓管功能障碍而无上感和鼻炎的儿童,其病因
Vasoconstrictor drugs are commonly used drugs for the treatment of secretory otitis media and eustachian tube dysfunction, but so far no published controlled clinical studies have confirmed its efficacy in the prevention and treatment of otitis media. The authors randomized 40 children with a history of secretory otitis media to bilateral tympanotomies to be double-blindly randomized into two groups: one group treated with 0.05% hydroxy-2-hydroxy-2-hydroxypyrazolol and one group with a placebo for nasal spray Observed on the Eustachian tube function. Children aged 5 to 15 years, 24 males and 16 females, no allergic or infectious rhinitis during the observation period, the middle ear without effusion. Nasal spray treatment was performed three times in two days, and one person was randomly selected each time before and after spraying. Eustachian tube function was determined using a modified blow-and-puff method and forced response test. Results There was no significant difference between the two groups, indicating that hydroxy-2-hydroxyzoline hydrochloride has no effect on eustachian tube function. However, the observation of this article is limited to children with severe eustachian tube dysfunction without symptoms and rhinitis, the etiology