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[目的]探讨柴苓调肝颗粒剂治疗大鼠非酒精性脂肪性肝病(NAFLD)的作用机制。[方法]采用高脂饲料的方法制备大鼠NAFLD模型,造模成功后,随机分为7组,柴苓调肝颗粒剂高、中、低剂量(高、中、低剂量)组,甘乐对照(甘乐)组、三七脂肝丸对照(三七脂肝丸)组、模型对照(模型)组和饮食控制组,另设正常对照(正常)组未予造模。各组分别给予相应的处理,4周后检测各组血清丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、总胆固醇(TC)、三酰甘油(TG)、肿瘤坏死因子α(TNF-α)和瘦素(LP)以及肝组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、体重及肝重指数的变化。[结果]高剂量组各项指标与模型组和饮食控制组比较差异均有统计学意义(P<0.05,<0.01),与正常组比较(P>0.05)。[结论]柴苓调肝颗粒剂可有效治疗实验性NAFLD。
[Objective] To investigate the mechanism of “Chai Ling Tiaogan Granule” in treating non-alcoholic fatty liver disease (NAFLD) in rats. [Method] The rat model of NAFLD was prepared by high-fat diet. After the model was successfully established, the rats were randomly divided into 7 groups. The rats in high, medium and low dose (high, medium and low dose) The control (Ganlu) group, the Sanchizhigangan control (Sanqizhigan Pill) group, the model control group (model group) and the diet control group, another normal control (normal) group was not model. After 4 weeks, the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglyceride (TG), tumor necrosis factor (TNF-α), leptin (LP), liver tissue and the changes of superoxide dismutase (SOD), malondialdehyde (MDA), body weight and liver mass index. [Results] The indexes in high dose group were significantly different from those in model group and diet control group (P <0.05, <0.01), compared with those in normal group (P> 0.05). [Conclusion] Chailing Tiao Gan Granules can effectively treat experimental NAFLD.