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［目的］比较放、化疗与单纯放射治疗鼻咽癌的生存率、局部控制率、远处转移发生率和毒副反应。［方法］从 １９９１年 ４ 月至 １９９３年 １０月， １２６例Ｎ２、Ｎ３期鼻咽癌患者随机分入放、化疗组和常规放疗组。放、化疗组放疗前、中及（或）放疗后各用 ＰＤＤ＋ ５－Ｆｕ化疗一个疗程，化疗方案为 ＰＤＤ２０ｍｇ／ｍ２， １至 ５天；５－Ｆｕ５００ｍｇ／ｍ２１至 ５天；两组放疗方法相同，全部病例用 ８ＭＶ光子线及６０ＣＯ 外照射，鼻咽部剂量６５Ｇｙ－７０Ｇｙ／６．５周－７周。颈淋巴结转移灶剂量６５Ｇｙ－７０Ｇｙ／６．５周－７周，颈淋巴结预防剂量５０Ｇｙ／５周。 ［结果］放、化疗组和单放组鼻咽肿瘤完全消退率分别为９３．６ ％和８５．７％（Ｐ＞０．０５），颈部转移淋巴结完全消退率分别为８４．１％ 和５７．１％（Ｐ＜０．０５）；两组３年生存率分别为６８．３％和５２．４％（Ｐ＞０．０５）；Ｎ２期鼻咽癌患者３年生存率分别为７５．５％和５８．７％ （Ｐ＞０．０５），Ｎ３期鼻咽癌患者３年生存率分别为５０． ０％和３５．３％（Ｐ＞０．０５）；３年鼻咽部肿瘤控制率两组分别为对４％和５７．１％ （Ｐ＜０．０５），颈转移淋巴结控制率分别为６９．８％和５２．３?
[Objective] To compare the survival rate, local control rate, distant metastasis incidence and toxicity of radiotherapy and chemotherapy and radiotherapy alone for nasopharyngeal carcinoma. [Methods] From April 1991 to October 1993, 126 patients with N2 and N3 nasopharyngeal carcinoma were randomly divided into radiotherapy and chemotherapy group and conventional radiotherapy group. Put the chemotherapy group before, during and / or after radiotherapy with PDD + 5-Fu chemotherapy for a course of chemotherapy for PDD20mg / m2, 1 to 5 days; 5-Fu500mg / m21 to 5 days; the same two groups of radiotherapy methods , All cases with 8MV photon line and 60CO external irradiation, nasopharyngeal dose 65Gy-70Gy / 6.5 weeks -7 weeks. Cervical lymph node metastases dose 65Gy-70Gy / 6.5 weeks -7 weeks, prevention of cervical lymph node dose 50Gy / 5 weeks. [Results] The complete regression rate of nasopharyngeal carcinoma in radiotherapy, chemotherapy and radiotherapy alone group was 93.6% and 85.7% (P> 0.05), and the complete regression rate of cervical lymph node metastasis was 84.1% and 57.1% (P <0.05). The 3-year survival rates of the two groups were 68.3% and 52.4% respectively (P> 0.05). The 3-year survival rates of patients with stage N2 nasopharyngeal carcinoma were 75 .5% and 58.7% respectively (P> 0.05). The 3-year survival rates of patients with N3 stage nasopharyngeal carcinoma were 50% and 50% respectively. 0% and 35.3%, respectively (P> 0.05). The control rates of nasopharyngeal tumors in 3 years were 4% and 57.1% (P <0.05), and the control rates of cervical lymph node metastasis were 69.8% and 52.3?