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对 1 995年青岛地区患病真鲷肝脏、肠上皮组织、肾脏、鳃等组织进行电镜观察 ,发现一种球形病毒 ,该病毒具有囊膜 ,直径为 80～ 1 0 0nm ,在核和细胞质中均形成不规则形态包涵体 ;细胞病理变化表现为核内染色质变性 ,核膜水肿变形且部分溶解 ,内质网膨胀 ,胞质内有大量游离核糖体分布 ,线粒体外膜及内嵴变形且有少量溶解。
In 1995, the diseased sea bream liver, intestinal epithelial tissue, kidney, gill and other tissues from Qingdao were examined by electron microscopy and found to be a spherical virus having a membrane with a diameter of 80-100 nm. The nuclei and cytoplasm All formed irregular inclusions; cytopathological changes manifested as chromatin degeneration within the nucleus, edema and deformation of the nuclear membrane partially dissolved, endoplasmic reticulum swelling, a large number of free ribosome distribution in the cytoplasm, mitochondrial outer membrane and inner cristae deforming A small amount of dissolved.