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目的:研究金氏痔痛贴对实验性大鼠的止血作用。方法:将清洁级SD大鼠随机分为6组,即对照组、云南白药组、赋形剂组及金氏痔痛贴大、中、小剂量组,测定大鼠的凝血时间、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fg)值及血小板聚集功能。结果:金氏痔痛贴能显著缩短模型大鼠的凝血时间、PT、TT、APTT,并能增强大鼠的血小板聚集功能,均具有统计学意义(P<0.01),但对于Fg,不具有统计学意义(P>0.05),金氏痔痛贴上述指标与云南白药组相比,不具有统计学意义(P>0.05)。结论:金氏痔痛贴能显著缩短凝血时间、PT、TT和APTT,并能增强大鼠的血小板的聚集功能,该药具有良好的止血作用。可作为临床痔疮出血的止血药物,其止血机制可能与促进凝血过程中的凝血酶原和凝血活酶的生成、增强血小板的聚集功能有关。
Objective: To study the hemostatic effect of King’s hemorrhoid pain sticker on experimental rats. Methods: The clean grade SD rats were randomly divided into 6 groups: control group, Yunnan Baiyao group, excipient group and Jinshi hemorrhoid pain sticking large, middle and small dose groups. The clotting time, Time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fg) and platelet aggregation function. Results: King’s hemorrhoids pain paste can significantly reduce the clotting time, PT, TT, APTT, and enhance platelet aggregation in rats, both of which have statistical significance (P <0.01), but not for Fg Statistical significance (P> 0.05), Jin Hemorrhoid pain paste the above indicators compared with Yunnan Baiyao group, not statistically significant (P> 0.05). Conclusion: King’s hemorrhoids pain paste can significantly shorten the clotting time, PT, TT and APTT, and can enhance the platelet aggregation in rats, the drug has a good hemostatic effect. It can be used as a hemostatic drug for hemorrhoids hemorrhage. Its hemostatic mechanism may be related to the promotion of the production of prothrombin and thromboplastin during coagulation and the enhancement of platelet aggregation.