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为探讨山良菪碱抗休克的机制,将15只失血性休克狗分为两组进行实验。山莨菪碱组:动物失血后静滴山莨菪碱(10mg/kg)20分钟;对照组则静滴同量生理盐水。实验过程中,在失血前、休克期和回输血液后分别从股动脉采血检查红细胞形态及其变形能力。结果:对照组在休克一小时和二小时,红细胞有部分皱缩并且变形能力降低,与休克前比较有显著性差异(P<0.05)。山茛菪碱组的红细胞形态和变形能力在失血前后则无明显差异,甚至在失血后第一小时其变形能力有所提高。以上说明山茛菪碱有维持正常红细胞形态和变形能力的作用。
In order to explore the mechanism of anti-shock of NS, 15 hemorrhagic shock dogs were divided into two groups for experiments. Anisodamine group: Anisodamine (10mg / kg) was intravenously given to the animals for 20 minutes after the blood loss; the control group was given the same amount of normal saline. During the experiment, blood samples were collected from the femoral artery before shock, shock and blood transfusion to examine the morphology and the deformability of erythrocytes. Results: In the control group one hour and two hours after shock, the erythrocytes partially collapsed and their deformability decreased, which was significantly different from that before shock (P <0.05). Anisodamine group of erythrocyte morphology and deformability before and after blood loss was no significant difference, even after the first hour of blood loss, its deformation ability has increased. The above shows that anisodamine maintains the normal erythrocyte morphology and deformability.