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已经证明,P物质(简称SP)是一种肽类神经递质,对躯体痛觉的调节有重要作用。本文检测了SP对内脏痛反应的作用。 材料和方法 选用250～300克的雄性大鼠。部分动物实验前分别在中脑导水管周围灰质(简称PAG,Ap~+6.5,SD0.5～1,V~-5.5～6)以及PAG外侧1～2mm(SD2～3,其它参数同前)埋置外径0.75mm的不锈钢套管。大鼠活动恢复正常后,在麻醉下于腹膜后分离左侧内脏大神经,阻断其外周传导功能,在中枢端埋置保护刺激电极。以电刺激内脏大神经中枢端模拟内脏痛。置左颈动脉插管以观察血压动态。大鼠完全清醒后,
It has been demonstrated that Substance P (SP) is a peptide neurotransmitter that plays an important role in the regulation of somatic pain. This article examined the effect of SP on visceral pain. Materials and methods Male rats weighing 250-300 g were used. Some animals before the experiment, respectively, in the midbrain periaqueductal gray (PAG, Ap ~ + 6.5, SD0.5 ~ 1, V ~ -5.5 ~ 6) and outside the PAG 1 ~ 2mm (SD2 ~ 3, other parameters with the former) Buried 0.75mm OD stainless steel sleeve. Rat activity returned to normal after anesthesia in the left retroperitoneal visceral nerve separation, blocking the peripheral conduction function, buried in the central protection stimulation electrodes. To stimulate the visceral nerve center to simulate visceral pain. Left carotid artery catheterization to observe the dynamic blood pressure. After rats were fully awake,