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目的:肾移植的排斥反应易导致纤溶功能改变,本文旨在探讨肾移植患者移植前后的纤溶改变的机理及临床意义。方法:20例患者手术前、后一天、三天、一周分测①t-PA、②PAI:A、③PLG:A、④PLM:A、均为发色底物法⑤D-Dimer ELLSA法。结果:[1]患者术前①②③④项较正常组差异明显;[2]患者术后三次②⑤明显高于正常组和术前[3]患者术后第三天除D二聚体外,其余均较第一天、一周结果相差显著。结论:重型肾病本身易形成血栓,术前亦可见局限性纤溶活性增强。肾移植之排斥反应亦可导致血栓形成,致继发性纤溶元进,定期检测有利于了解排斥反应的出现时间与严重程度,以便及早采取措施.提高移植的成功率。
OBJECTIVE: The renal transplant rejection often leads to changes of fibrinolytic function. This paper aims to investigate the mechanism and clinical significance of fibrinolysis before and after renal transplantation. Methods: T-PA, ②PAI: A, ③PLG: A and ④PLM: A in 20 patients before operation, one day after the operation, three days and one week after operation were all detected by D-Dimer ELLSA method. Results: [1] patients before surgery ① ② ③ ④ items than the normal group significant differences; 2 patients after three times ② ⑤ was significantly higher than the normal group and preoperative [3] patients on the third postoperative day except D dimer, the rest were more The first day, the results of a significant difference between the week. Conclusion: Severe nephropathy is easy to form thrombus itself, also showed limited fibrinolytic activity increased preoperatively. Rejection of renal transplantation can also lead to thrombosis, resulting in secondary fibrinolysis, regular testing is conducive to understand the timing and severity of rejection appear in order to take early measures to improve the success rate of transplantation.