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目的研究探讨侵袭性非霍奇金淋巴瘤的预后影响因素。方法回顾性分析137例侵袭性非霍奇金淋巴瘤的临床特征,结合随访资料,应用SPSS 10.0统计软件进行生存分析,并对其预后影响因素进行多因素分析。结果放化疗后达CR者35例(25.5%),其中近期CR 31例(22.6%), PR 67例(48.9%),SD 6例(4.3%),PD 29例(21.2%),总有效率为74.5%。4年总生存率为70.8%,4年无复发生存率为42.7%。Cox模型多因素分析显示,临床分期为Ⅲ～Ⅳ期、PS评分≥2分、累及淋巴结外病变数≥2个与预后关系密切,具有统计学意义。结论侵袭性非霍奇金淋巴瘤通过放化疗综合治疗,生存率有了较大提高。对于不同类型的NHL如何实施个体化的治疗方案,仍需进一步探讨。
Objective To study the prognostic factors of invasive non-Hodgkin’s lymphoma. Methods Retrospective analysis of 137 cases of invasive non-Hodgkin’s lymphoma clinical features, combined with follow-up data, the application of SPSS 10.0 statistical software for survival analysis, and its prognostic factors multivariate analysis. Results CR was 35 (25.5%) after radiotherapy and chemotherapy. Among them, 31 cases (22.6%) were CR, 67 cases (48.9%) were CR, 6 cases were SD (21.2%) and 29 cases were PD Efficiency is 74.5%. 4-year overall survival was 70.8%, 4-year recurrence-free survival rate was 42.7%. Cox model multivariate analysis showed that the clinical stage Ⅲ ~ Ⅳ, PS score ≥ 2 points, lymph nodes involving more than 2 lesions and prognosis are closely related, with statistical significance. Conclusion Invasive non-Hodgkin’s lymphoma by radiotherapy and chemotherapy combined treatment, survival rate has been greatly increased. There is still a need for further discussion of how to implement individualized regimens for different types of NHLs.