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本文应用ＣＤ２、ＣＤ４、ＣＤ８单克隆抗体通过ＡＰＡＡＰ桥联酶标技术检测了３９例海洛因依赖者Ｔ细胞阳性率的变化，结果表明：海洛因滥用者平均Ｔ细胞阳性率（ＣＤ４５３．２±ｓ１０．９）比健康人（６２．０±ｓ７．１）为低（Ｐ＜０．０１），ＣＤ４／ＣＤ８比值也比健康人降低（Ｐ＜０．０５），ＣＤ２、ＣＤ８无明显改变；不同滥用者经住院治疗８－１２ｄ后，抽血测定Ｔ细胞阳性率，ＣＤ２为８２．５±ｓ６．８，较脱毒治疗前为低（Ｐ＜０．０１）。ＣＤ４、ＣＤ８及ＣＤ４／ＣＤ８无明显改变。Ｔ细胞阳性率在男女性别之间，吸海洛因与褴用度冷丁、黄皮、二氢埃托啡之间，烫吸与注射比较，吸毒量＜１．０ｇ·ｄ－１与吸毒量＞１．０ｇ·ｄ－１，吸毒时间（＞１８月）与吸毒时间短（＜１８月）比较，Ｔ细胞阳性率均无明显差别。
In this paper, we detected the positive rate of T cells in 39 cases of heroin dependent patients by using the monoclonal antibody of CD2, CD4, CD8 and APAAP bridge. The results showed that the positive rate of T cells in heroin abusers (CD453.2 ± s10.9 ) Was lower than that of healthy people (62.0 ± s7.1) (P <0.01), and the ratio of CD4 / CD8 was also lower than that of healthy people (P <0.05) After 8-12 days of hospitalization, the positive rate of T cells was determined by blood sampling. The CD2 was 82.5 ± s6.8, which was lower than that before detoxification (P <0.01). CD4, CD8 and CD4 / CD8 no significant change. The positive rate of T cells between male and female, smoking heroin and razor use of cold Ding, yellow skin, dihydroetorphine, hot suction compared with injection, drug consumption <1.0g · d-1 and drug consumption> 1 .0g · d-1, drug-taking time (> 18 months) and drug-taking time was short (<18 months), T cells were no significant difference in the positive rate.