目的:分析胎儿先天性疾病的产前诊断现状,探讨产前诊断对胎儿疾病转归的影响。方法:选取郑州大学第三附属医院2009年9月～2010年8月期间,疑难病例产前多科会诊323例,进行胎儿及新生儿随访。比较产前与产后诊断的符合率,探讨多科会诊后胎儿处理意见对胎儿及新生儿预后所造成的影响。结果:①疑难病例产前多科会诊323例中,胎儿因素会诊303例(93.8%),母体因素会诊8例(2.5%),脐带、胎盘因素会诊12例(3.7%)。②因胎儿因素会诊的303例中107例选择人工流产(35.3%),人工流产后诊断符合率100.0%;24例新生儿出生后接受手术治疗,12例出生后新生儿死亡。③胎儿因素会诊的主要疾病为颅脑系统异常78例(24.1%)、胎儿泌尿系统异常64例(19.8%)、胎儿多发畸形48例(14.9%)、胎儿心血管系统异常27例(8.4%)。④因胎儿多发畸形、多囊肾、胸部占位性病变,骨骼系统异常和遗传性疾病的人工流产终止妊娠率均高于50%。⑤产前诊断为胎儿肾盂扩张26例,有15例在孕期或出生后的随访中消退;产前诊断为胎儿脑室扩张28例,有17例在孕期或出生后的随访中消退。结论:产前会诊中胎儿因素导致的疾病占绝大多数,其中颅脑系统疾病发病率最高,产前会诊后,部分严重的胎儿疾病人工流产率较高。产前诊断的胎儿肾盂扩张或脑室扩张,随访中有较高的消退率。 OBJECTIVE: To analyze the status of prenatal diagnosis of congenital fetal diseases and to explore the influence of prenatal diagnosis on the outcome of fetal diseases. Methods: During the period from September 2009 to August 2010, the Third Affiliated Hospital of Zhengzhou University, 323 cases of prenatal polygamous consultation of difficult cases were followed up for fetal and neonatal follow-up. Comparing the coincidence rate of prenatal and postnatal diagnosis, to discuss the impact of multi-disciplinary consultation on fetal and neonatal prognosis. RESULTS: ① Among the 323 cases of difficult prenatal diagnosis, there were 303 cases (93.8%) of consultation with fetal factors, 8 cases (2.5%) of consultation with maternal factors, and 12 cases (3.7%) with umbilical cord and placenta consultation. 107 cases of induced abortion (35.3%) were selected from 303 cases of fetal factors. The coincidence rate after artificial abortion was 100.0%. 24 cases of newborns received surgery after birth and 12 cases of neonatal death after birth. (3) The main diseases of fetus consultation were craniocerebral system abnormalities in 78 cases (24.1%), fetus urinary system abnormalities in 64 cases (19.8%), multiple fetal malformations in 48 cases (14.9%), fetus cardiovascular system abnormalities in 27 cases (8.4% ). ④ due to fetal multiple deformities, polycystic kidney disease, chest space occupying lesions, skeletal system abnormalities and genetic diseases abortion termination pregnancy rates were higher than 50%. ⑤ prenatal diagnosis of fetal pelvis dilatation in 26 cases, 15 cases of pregnancy or postnatal follow-up subsided; prenatal diagnosis of fetal ventricle dilatation in 28 cases, 17 cases during pregnancy or postnatal follow-up subsided. Conclusion: Prenatal consultation results in the majority of diseases caused by fetal factors, of which the highest incidence of craniocerebral diseases, prenatal consultation, some of the serious fetal diseases induced abortion rate is higher. Prenatal diagnosis of fetal pelvis dilatation or ventricular dilatation, follow-up in a higher rate of regression.