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目的探讨高频震荡通气(HFOV)联合肺表面活性物质(PS固尔苏)治疗新生儿重症呼吸衰竭的临床疗效。方法共63例急性低氧血症呼吸衰竭新生儿，入选标准为氧合指数(OI)>20，在机械通气(常频或高频)下，患儿随机被给予ps或无ps，比较常频机械通气CMV+ps、HFOV、HFOV+PS组间疗效。结果治疗12 h，HFOV+PS组中PaO2/ FiO2变化最大，氧合指数下降最快。治疗24 h，HFOV、HFOV+PS组PaO2/ FiO2均有明显变化，两组分别与CMV+PS组比较，差异均有统计学意义(<0.05)；CMV+PS、HFOV、HFOV+PS组OI均明显下降，其中以HFOV+iNO组下降最显著，与各组比较差异均有统计学意义(20, mechanical ventilation (normal frequency or high frequency), the children were given a random ps or no ps, more often frequency mechanical ventilation CMV + ps, HFOV, between HFOV + ps group ef icacy. Results Treatment after 12h, HFOV+PS group PaO2/FiO2 biggest changes, oxygenation index fel fastest. after 24h, HFOV, HFOV+PS group PaO2/FiO2 changed significantly in both groups respectively CMV+PS group, the dif erence was statistical y significant ( <0.05);CMV+PS, HFOV, HFOV+PS group OI decreased significantly, which HFOV+iNO group decreased most significantly, compared with the dif erences in each group were statistical y significant( <0.01). Conclusion HFOV combined PS treatment of neonatal respiratory failure with severe best ef ect, the two have a synergistic ef ect.