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背景:左心室肥厚(left ventricular hypertrophy,LVH)患者红细胞内游离Ca2~+浓度、红细胞膜Ca2~+-Mg~2+-ATP酶活性的变化尚不清楚。 目的:探讨原发性高血压(essential hypertension,EH)患者伴LVH和不伴LVH红细胞内游离Ca2~+浓度、红细胞膜Ca2~+-Mg2~+-ATP酶活性的变化及其相互关系,揭示了原发性高血压的发病机制,为康复措施的介入提供理论依据。 设计:以诊断为依据的病例对照研究。 地点、对象和方法:检测30例来源于解放军第四军医大学唐都医院健康体 检自愿参加研究的正常血压者(正常血压组);82例来源于本院的轻度和中度EH患者(高血压组)(其中LVH组40例,非LVH组42例)外周血红细胞内Ca~(2+)浓度及红细胞膜Ca~(2+)-Mg~(2+)-ATP酶活性。 主要观察指标:血压正常者和EH患者外周血红细胞Ca~(2+)浓度和红细胞膜Ca~(2+)-Mg~(2+)-ATP ase活性测定结果比较;LVH和非LVH患者性别,年龄,体质量指数,心率,收缩压,舒张压,平均压,IVST,PWT,EDD,LVMI,外周血红细胞内Ca~(2+)浓度,红细胞膜Ca~(2+)-Mg~(2+)-ATP酶活性测定结果比较;EH患者LVH与Ca~(2+)的相关性。 结果:①EH组外周血红细胞内Ca~(2+)浓度显著高于正常血压组[(1013.5±90.4),(1286.1±95.7)nmol/L,P<0.01],红细胞膜Ca~(2+)-Mg~(2+)-ATP酶活性明显低于正常血压组[
BACKGROUND: Changes in free Ca2 + concentration in erythrocytes and Ca2 + -Mg2 + -ATPase activity in erythrocyte membrane in patients with left ventricular hypertrophy (LVH) are unknown. OBJECTIVE: To investigate the changes of Ca2 + -Mg2 + -ATPase activity in erythrocyte membrane and the relationship between free Ca 2+ concentration in patients with essential hypertension (EH) and non-LVH erythrocytes The pathogenesis of essential hypertension provides a theoretical basis for the intervention of rehabilitation measures. Design: A case-control study based on diagnosis. Location, Subjects and Methods: Totally 30 patients with normal blood pressure (normotensive group) who voluntarily participated in the health examination at Tangdu Hospital of the Fourth Military Medical University of the People’s Liberation Army were detected. 82 patients with mild and moderate EH Blood pressure group) (including 40 cases of LVH group and 42 cases of non - LVH group), intracellular Ca2 + concentration in erythrocytes and Ca2 + - Mg2 + - ATPase activity in erythrocytes were measured. MAIN OUTCOME MEASURES: Comparison of Ca ~ (2 +) - Ca ~ (2+) - Mg ~ (2 +) - ATPase activity of erythrocytes in normotensives and EH patients; gender of patients with LVH and non-LVH Age, body mass index, heart rate, systolic blood pressure, diastolic blood pressure, mean pressure, IVST, PWT, EDD, LVMI, erythrocyte Ca 2+ concentration 2 +) - ATPase activity, and the correlation between LVH and Ca ~ (2+) in EH patients. Results: ① The concentration of Ca 2+ in peripheral blood erythrocytes in EH group was significantly higher than that in normotensive group [(1013.5 ± 90.4), (1286.1 ± 95.7) nmol / L, P <0.01] -Mg ~ (2 +) - ATPase activity was significantly lower than that of normotensive group [