探讨复合茶的降脂作用,为茶叶的降脂机理及复合茶开发和应用提供理论支撑.SPF级雄性KM小鼠随机分为模型对照组(NK)、阳性对照组(YK)、空白对照组(CK)和复合茶处理组(DH)4组,每个组10只;灌胃给予复合茶30 d后,分析复合茶对高脂血症小鼠的体重、肝系数和肝组织形态以及肝脏有机酸代谢的影响.结果表明:与CK组相比,NK组小鼠的体重极显著上升,而DH组的增重、肝体比均无显著差异;共检测到52种差异显著有机酸代谢物,与CK组相比,DH组中有B-脲基异丁酸和N-乙酰天冬氨酰谷显著上调,肌酸等14种有机酸代谢物显著下调;YK组中有精氨基琥珀酸等13种显著上调,绿原酸等17种显著下调.研究表明:复合茶具有较强的降脂作用和肝脏保护作用,且效果优于YK组(血脂康处理);其可能原因是复合茶调节绿原酸等有机酸代谢物及其代谢途径,改善了高脂膳食诱导的小鼠血脂异常,从而达到减肥降脂作用.“,”The lipid-lowering effects of compound tea were investigated to determine the mechanism underlying its action and provide theoretical support for the development and application of this compound tea. Specific pathogen-free male Kunming mice were randomly divided into four groups: a model control group (NK), positive control group (YK), blank control group (CK), and compound tea treatment group (DH), with 10 mice in each group. After 30 days of intragastric administration of compound tea, the body weight, liver coefficient, liver morphology, and liver metabolism of organic acids were analyzed in mice with hyperlipidemia. The weight of mice in the NK group was significantly increased compared to that of the mice in the CK group, whereas the weight gain and liver-to-body ratio of mice in the DH group exhibited no significant difference. Fifty-two differential organic acid metabolites were detected. Compared to the CK group, b-ureaisobutyric acid and n-acetyl-aspartyl-glutamate in the DH group were significantly upregulated, whereas creatine and 14 other organic acids were significantly downregulated. In the YK group, 13 organic acids, including argininosuccinic acid, were upregulated, whereas 17 organic acids, including chlorogenic acid, were downregulated. Compound tea had a better ability to regulate blood lipids compared with the YK (positive control, Xuezhikang). This may be because compound tea can regulate the metabolism of organic acids, such as chlorogenic acid, and their associated metabolic pathways, as well as ameliorate dyslipidemia induced by a high-fat diet in mice, thereby reducing body weight and blood lipid levels.