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目的研究应用酚妥拉明与垂体后叶素对肝硬化门静脉高压上消化道出血患者实施治疗的临床效果。方法 48例肝硬化门静脉高压上消化道出血患者,随机分为对照组和治疗组,每组24例。对照组患者采用垂体后叶素治疗,治疗组患者采用酚妥拉明与垂体后叶素联合治疗。观察两组的临床效果。结果治疗组患者上消化道出血症状消失时间和临床药物治疗计划实施总时间明显短于对照组,药物治疗消化道出血期间出现不良反应的例数明显少于对照组,肝硬化门静脉高压上消化道出血疾病药物治疗效果明显优于对照组,差异均具有统计学意义(P<0.05)。结论采用酚妥拉明与垂体后叶素联合治疗肝硬化门静脉高压上消化道出血患者,可提高治疗效果,减少不良反应发生,具有临床推广价值。
Objective To study the clinical effect of phentolamine and pituitrin in the treatment of patients with cirrhosis and portal hypertension. Methods Forty-eight patients with cirrhosis and portal hypertension with upper gastrointestinal bleeding were randomly divided into control group and treatment group, with 24 cases in each group. Patients in the control group were treated with pituitrin, and patients in the treatment group were treated with phentolamine combined with pituitrin. The clinical effects of the two groups were observed. Results The disappearance time of upper gastrointestinal bleeding and the total time of clinical drug treatment in the treatment group were significantly shorter than those in the control group. The number of adverse reactions in the treatment of gastrointestinal bleeding was significantly less than that in the control group. The incidence of portal hypertension in the upper gastrointestinal tract Hemorrhagic disease drug treatment was significantly better than the control group, the differences were statistically significant (P <0.05). Conclusions The combination of phentolamine and pituitrin in the treatment of patients with portal hypertension caused by upper gastrointestinal hemorrhage can improve the therapeutic effect and reduce the occurrence of adverse reactions, and has clinical value of popularization.