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目的:研究左归丸对谷氨酸(Glutamic acid)诱导的小鼠神经毒性的可能保护作用。方法:除对照组外,其他组小鼠接受谷氨酸单钠(monosodium glutamate,MSG,4.0g/kg)灌胃,每日一次,连续给药10日。第11天起,治疗组分别接受左归丸(1.0,2.0,4.0 g/kg,ig),之后通过小鼠的行为学实验、脑海马组织病理学和脑组织抗氧化指标检测,分析MSG所引起的功能和形态学上的变化以及左归丸的可能的保护作用。结果:左归丸显著修复MSG对小鼠行为、脑海马组织病理的不良影响,明显升高小鼠脑组织中超氧化物歧化酶(SOD)水平,而显著降低丙二醛(MDA)。结论:左归丸对MSG诱导的小鼠神经毒性有一定的保护作用,其保护作用机制可能与其改善小鼠抗氧化指标水平,增强机体的抗氧化能力有关。
Objective: To study the possible protective effect of Zuo Gui Pill on the neurotoxicity induced by Glutamic acid in mice. Methods: Except for the control group, the mice of other groups received intragastric administration of monosodium glutamate (MSG, 4.0g / kg) once daily for 10 consecutive days. On the 11th day, the Zuogui Pill (1.0,2.0,4.0 g / kg, ig) were respectively received in the treatment group. Afterwards, behavioral test, hippocampal histopathology and anti-oxidative index of brain tissue were used to examine the effect of MSG Induced functional and morphological changes, and possible protective effects of Zuogui Pills. Results: Zuogui Pill could significantly repair the adverse effects of MSG on the behavior and hippocampal histopathology in mice and significantly increase the level of superoxide dismutase (SOD) in brain tissue of mice and significantly reduce the malondialdehyde (MDA). Conclusion: Zuogui pill can protect MSG-induced neurotoxicity in mice, and its protective mechanism may be related to improving the level of anti-oxidative index and enhancing the antioxidant capacity of mice.