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目的了解抗精神病药对住院精神疾病患者血糖的影响。方法对2002年1月~2004年12月服用抗精神病药引起血糖升高的135例精神疾病患者的资料进行回顾性分析。结果抗精神病药引起血糖升高发生率为10.2%,服用抗精神病药患者病程越长、年龄越大越易引起血糖升高,非典型抗精神病药引起血糖升高大于典型抗精神病药。结论长期使用抗精神病药可能会导致血糖升高,尤以氯氮平为甚。
Objective To understand the effect of antipsychotics on blood glucose in hospitalized patients with mental illness. Methods A retrospective analysis was conducted on the data of 135 patients with mental illness who took antipsychotic drugs to cause hyperglycemia from January 2002 to December 2004. Results The incidence of hyperglycemia caused by antipsychotics was 10.2%. The longer the patients taking antipsychotics, the older the more likely to cause hyperglycemia. The atypical antipsychotics caused more blood sugar to rise than the typical antipsychotics. Conclusion Long-term use of antipsychotics may lead to elevated blood glucose, especially clozapine.