论文部分内容阅读
目的分析2型糖尿病及糖尿病肾病患者血清白介素18(IL-18)及C反应蛋白(C-RP)水平与尿白蛋白排泄率(UAER)的相关性。方法纳入早期糖尿病肾病患者(DN组)、新诊断2型糖尿病无微量白蛋白尿患者(T2DM组)及健康对照者(NC组)各30例。分别测定3组患者的UAER及血清IL-18、C-RP水平,并分析其相关性。结果 (1)T2DM和DN组的血清IL-18及C-RP水平均明显高于对照组,且DN组升高更明显,各组间的差异均有统计学意义。(2)直线相关分析显示,UAER与血清IL-18、C-RP均呈正相关(分别为r=0.457,P<0.01和r=0.31 7,P<0.05)。结论血清IL-18、C-RP水平的升高程度可能对DN的严重程度有一定提示作用。
Objective To analyze the correlation between serum interleukin 18 (IL-18) and C-reactive protein (C-RP) and urinary albumin excretion rate (UAER) in type 2 diabetic patients and diabetic nephropathy patients. Methods Thirty patients with early diabetic nephropathy (DN group), 30 newly diagnosed type 2 diabetic patients without microalbuminuria (T2DM group) and healthy controls (NC group) were enrolled. The levels of UAER, serum IL-18 and C-RP in 3 groups were measured and their correlations were analyzed. Results (1) Serum levels of IL-18 and C-RP in T2DM and DN groups were significantly higher than those in control group, and DN group increased more obviously. The differences among the groups were statistically significant. (2) The linear correlation analysis showed that there was a positive correlation between UAER and serum IL-18 and C-RP (r = 0.457, P <0.01 and r = 0.31 7, P <0.05). Conclusions The elevated level of serum IL-18 and C-RP may have certain cues to the severity of DN.