肥胖症是当今危急人类健康的一大难题.研究肥胖的机制,并达到防御和治疗肥胖症是研究的最终目的.自2001年以来,研究发现,黑色素浓集激素受体2(melanin-concentrating hormonereceptor-2,MCHR2)与肥胖间存在紧密联系.但研究进展缓慢,主要瓶颈是没找到合适的动物模型.本课题通过对多种动物的筛选,首次发现豚鼠大脑中存在MCHR2的高度表达,并运用RT-PCR、Northern印迹和Western印迹等方法进行了验证.这一结果为将豚鼠作为MCHR2功能研究的动物模型提供了实验依据. Obesity is a major problem in today’s critical human health.Research on the mechanism of obesity, and achieve the defensive and treatment of obesity is the ultimate goal of the study.Since 2001, the study found that melanin-concentrating hormone receptor 2 (melanin-concentrating hormonereceptor -2, MCHR2) and obesity, but the research progress is slow, the main bottleneck is not to find a suitable animal model.This topic for a variety of animal screening, for the first time found in the guinea pig brain MCHR2 expression and use RT-PCR, Northern blotting and Western blotting.The results provided the experimental basis for using guinea pig as an animal model for MCHR2 functional studies.