自１９７８年利用Ｘ－射线单晶衍射方法，确定铜蓝蛋白的活性中心是铜离子，它与２个组氨酸残基的氮原子、１个蛋氨酸残基的醚硫原子和１个半胱氨酸残基的巯基硫原子形成畸变的四面体［１］以来，人们合成了许多带杂环配位端基的配体，例如带咪唑、苯并咪唑、吡啶、吡唑等... Since 1978, using X-ray single crystal diffraction method to determine the active center of ceruloplasmin copper ion, which is two nitrogen atoms histidine residue, a methionine residue ether sulfur atom and a cysteine Since the thiol sulfur atom of the amino acid residue forms a distorted tetrahedron [1], many ligands with heterocyclic coordination end groups have been synthesized, such as imidazole, benzimidazole, pyridine, pyrazole and so on.