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目的:探讨痴复康对痴呆大鼠学习、记忆能力影响。方法:选购体重与灵活性基本一致的纯种SD雄性大鼠80只,随机分为4组,即痴复康组、脑复康组、模型组和空白组,每组又分为观察学习获得和记忆巩固能力两组,每组10只。前3组复制血管性痴呆动物模型,空白组经颈内动脉注射生理盐水。4组动物分别灌服痴复康、脑复康、自来水,观察药物对痴呆大鼠学习、记忆能力的影响。结果:经痴复康治疗后的大鼠,其学习、记忆能力明显改善,与模型组相比具有显著性差异(P<0.01)。结论:与目前认识比较一致的治疗痴呆的有效药物脑复康相比,痴复康则优于脑复康(P<0.05)。
Objective: To investigate the effect of Zhifukang on learning and memory in dementia rats. Methods: 80 male SD rats with the same body weight and flexibility were randomly divided into 4 groups, namely Zhifu Kang group, Naofukang group, model group and blank group. Each group was divided into observation and learning. Acquisition and memory consolidation ability in two groups, 10 in each group. The first three groups were used to replicate the animal model of vascular dementia. The blank group was injected with normal saline through the internal carotid artery. The rats in the four groups were fed Zhifukang, Naofhongkang and tap water, respectively, to observe the effects of drugs on learning and memory ability of dementia rats. RESULTS: The rats’ learning and memory abilities were significantly improved after treatment with Xifukang, which was significantly different from that of the model group (P<0.01). Conclusion: Compared with the current understanding of the brain detoxification treatment of brain rehabilitation, compared with the general treatment, decoction is better than Naofukang (P <0.05).