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本实验观察了泥炭腐植酸对小鼠胃肠推进运动的影响,结果如下: 1.腹腔注射腐植酸后,小肠内炭末胶液推进距离明显减少,表明腐植酸对胃肠道的推进运动有抑制作用,并有剂量依赖关系。腐植酸的阔剂量是0.5mg/kg,最大剂量是20mg/kg。 2.酚妥拉明(10mg/kg)能明显地减弱腐植酸的抑制作用,提示腐植酸对胃肠推进运动的影响是通过α-受体的活动实现的。 3.以最大剂量的腐植酸静脉、皮下注射或灌胃后,对胃肠推进运动无影响。
In this experiment, we observed the effects of peat humic acid on gastrointestinal motility in mice. The results were as follows: 1. After peritoneal injection of humic acid, the advancing distance of the charcoal in the small intestine was significantly reduced, indicating that humic acid has a promoting effect on the gastrointestinal tract. Inhibitory effects, and dose-dependent. The wide dose of humic acid is 0.5 mg/kg and the maximum dose is 20 mg/kg. 2. Phentolamine (10mg/kg) can significantly reduce the inhibitory effect of humic acid, suggesting that the effect of humic acid on gastrointestinal propulsion is achieved through the activity of α-receptors. 3. The maximal dose of humic acid, subcutaneous injection or intragastric administration had no effect on gastrointestinal propulsion.