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肝细胞生长因子是一种肾营养因子,具有诱导有丝分裂、促肾小管形态发生、抑制肾间质纤维化等作用,并证实其具有显著的抗细胞凋亡作用,能增加细胞增殖,促进受损肾脏的再生和肾功能的恢复。本文综述了肝细胞生长因子生物学特性、肾脏细胞凋亡特点及肝细胞生长因子对肾脏细胞凋亡的调控及具体机制。提示肝细胞生长因子可能是一种有潜力的治疗急慢性肾脏损伤的新型方法。
Hepatocyte growth factor is a kind of nephrotic factor, which has the function of inducing mitosis, promoting tubule morphogenesis, inhibiting renal interstitial fibrosis and so on, and it has obvious anti-apoptosis effect, can increase cell proliferation and promote damage Renal regeneration and renal function recovery. This article reviews the biological characteristics of hepatocyte growth factor, the characteristics of renal cell apoptosis and the regulation of hepatocyte growth factor on renal cell apoptosis and the specific mechanism. Prompted hepatocyte growth factor may be a potential new method of treatment of acute and chronic kidney injury.