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目的:探讨血红素氧合酶-2(HO-2)及胆红素与羊水过少及其围生儿预后的关系。方法:收集宝安区妇幼保健院2008年4月～2009年3月住院分娩的足月羊水过少、羊水偏少及正常羊水组孕产妇各30例,再分为围生儿预后不良及良好两组。应用SP免疫组化方法检测HO-2在胎盘组织中的表达,并测定其活性产物胆红素值。结果:①HO-2在羊水过少组胎盘组织中的表达较正常羊水组低,血清胆红素平均值在羊水过少组亦较正常羊水组低,差异均有统计学意义(P<0.05)。②HO-2在围生儿预后不良组胎盘组织中表达较围生儿预后良好组低,胆红素值在围生儿预后不良组亦较围生儿预后良好组低,差异均有统计学意义(P<0.05)。结论:HO-2及胆红素与羊水过少发病及其围生儿预后有关;可为临床监测羊水过少危险性提供可能的检测指标。
Objective: To investigate the relationship between heme oxygenase-2 (HO-2) and bilirubin in oligohydramnios and its prognosis. Methods: Maternal and Child Health Hospital of Baoan District collected from April 2008 to March 2009 hospitalized full term oligohydramnios, oligohydramnios and normal amniotic fluid group of 30 pregnant women, and then divided into poor prognosis perinatal and good two group. The expression of HO-2 in placenta was detected by SP immunohistochemistry, and the activity of bilirubin was measured. Results: ① The expression of HO-2 in placenta of oligohydramnios group was lower than that in normal amniotic fluid group, and the average value of serum bilirubin in oligohydramnios group was lower than that in normal amniotic fluid group (P <0.05) . ②The expression of HO-2 in placenta of poor perinatal prognosis group was lower than that in perinatal group, the bilirubin value was lower in perinatal poor prognosis group than that in perinatal group, the differences were statistically significant (P <0.05). CONCLUSION: HO-2 and bilirubin are associated with oligohydramnios and the prognosis of perinatal infants. It may provide a possible detection index for clinical monitoring of oligohydramnios.