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以糖精水为条件刺激 (conditionedstimulus,CS) ,免疫抑制剂 -环磷酰胺为非条件刺激 ((unconditionedstimulus,UCS) ,在两次CS -UCS结合训练后 ,观测不同时程再次单独呈现条件刺激对条件反射性免疫抑制和味觉厌恶性行为反应的变化以及大鼠杏仁核各亚核团内c fos蛋白表达的影响。结果表明 ,条件反射性免疫抑制作用在训练后第 5天较强 ,第 30天基本消失 ,而味觉厌恶性条件反射始终稳定保持到第 30天。条件反射组大鼠杏仁中央核c fos蛋白表达在第 5天非常密集 ,而第 30天明显减少 ,与细胞免疫功能改变在时程和趋势上具有一致性。通过c fos蛋白表达时程差异比较 ,提示杏仁中央核可能既与条件性的味觉厌恶性行为建立有关 ,也是参与介导CS诱导的免疫抑制效应的重要核团
Conditioned stimulus (CS) and immunosuppressant-cyclophosphamide (unconditionedstimulus, UCS) were stimulated with saccharin water separately. After two CS-UCS combined training, Conditioned reflex immunosuppression and taste-aversion behavior changes and the expression of c fos protein in the nuclei of rat amygdala.The results showed that conditional reflex immunosuppression was stronger on the fifth day after training, Day disappeared, while the taste-borne sexual conditioning reflex remained stable until day 30. The expression of c fos protein in the central almond nucleus of conditioned reflex rats was very dense on the fifth day, but significantly decreased on the 30th day, and the change of cellular immune function was Time course and trend.According to the difference of c fos protein expression time course, it is suggested that the central almond nucleus may be involved in both the conditioned taste aversion behavior and the important nucleus participating in the CS-induced immunosuppression