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目的比效相同剂量辛伐他汀(舒降之)隔日服药与每日服药对高脂血症的治疗效果。方法将2002年6月到2006年6月186例低密度脂蛋白胆固醇(LDL-C)升高和(或)总胆固醇(TC)、甘油三脂(TG)升高,高密度脂蛋白胆固醇(HDL-C)降低的患者随机分为隔日服药组与每日服药组,2组服用舒降之剂量均为20mg。检测所有患者空腹状态下服药前及服药后6周、服药后12周血脂水平,同时通过检测肝功能、肌酐等多项指标观察其副反应。结果经治疗2组 LDC-C、TC、TG 均有明显降低,HDL-C 轻度升高。治疗6周与12周后,2组血脂降低差异无显著性意义,副反应发生差异也无显著性意义。结论相同剂量舒降之隔日服药与每日服药疗效与安全性相似,但降低了医疗费用,提高了患者服药的依从性,故舒降之隔日服药对相对低危高脂血症患者作为冠心病一级预防。
The purpose of the same dose of simvastatin (Shu down) taking the next day and daily medication for the treatment of hyperlipidemia. Methods 186 cases of LDL-C and TC, TG were increased from June 2002 to June 2006. The levels of high density lipoprotein cholesterol HDL-C) patients were randomly divided into two groups: daily medication group and daily medication group. Both groups took 20 mg. All patients under fasting state before taking and after taking 6 weeks, 12 weeks after taking the blood lipid levels, and by detecting liver function, creatinine and other indicators to observe the side effects. Results After treatment, LDC-C, TC, TG were significantly decreased, and HDL-C slightly increased. After 6 and 12 weeks of treatment, there was no significant difference between the two groups in the reduction of blood lipids, and there was no significant difference in the side effects. Conclusion The same dose of antihypertensive medication and daily medication efficacy and safety similar, but lower medical costs and improve compliance of patients taking medication, so taking the second day of taking antihypertensive treatment of patients with relatively low risk of hyperlipidemia as coronary heart disease Primary prevention.