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实验证实辐射和化学致癌剂等因素造成的转化细胞系和人类许多恶性肿瘤细胞中都有野生型ｐ５３抑癌基因丢失或突变，他们在细胞转化和肿瘤的发生发展中具有重要作用，ｐ５３基因及其表达产物已成为近年来研究最多的基因之一。１ ｐ５３基因及表达产物的结构人ｐ５３基因位于１
Experiments confirmed that radiation and chemical carcinogens and other factors caused by transformation of cell lines and many human malignancies have wild-type p53 tumor suppressor gene loss or mutation, they play an important role in cell transformation and tumor development, p53 gene and Its expression product has become one of the most studied genes in recent years. Structure of p53 gene and its expression product The human p53 gene is located at 1