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目的通过多普勒超声测定左心室心肌运动指数评价心力衰竭患者应用卡维地洛治疗前后心功能的变化。方法收集哈尔滨医科大学第一临床医学院2004—2006年住院和门诊的患者,其中正常对照组50名,慢性心力衰竭组45例,观察治疗前和治疗后1个月、6个月时分别用多普勒超声测量左心室传统Tei指数(c-Tei)和组织多普勒Tei指数(t-Tei)、左室射血分数(LVEF)等指标。结果慢性心力衰竭组较正常对照组左心室舒张末期内径(LVEDd)、c-Tei和t-Tei明显增高(P<0.05),LVEF明显降低(P<0.05);卡维地洛治疗1个月时,c-Tei和t-Tei明显改善(P<0.05);治疗6个月时,c-Tei、t-Tei、LVEF、LVEDd和美国纽约心脏协会心功能分级较治疗前均明显改善(P<0.05)。结论应用Tei指数对心力衰竭患者心功能进行评价简便、可行,c-Tei和t-Tei具有同等作用。
Objective To evaluate the changes of cardiac function in patients with heart failure treated with carvedilol by Doppler echocardiography. Methods The patients admitted to the First Affiliated Hospital of Harbin Medical University from 2004 to 2006 were enrolled in the study. Among them, 50 were in the normal control group and 45 were in the chronic heart failure group. Before and after treatment, 1 month and 6 months after treatment, Doppler echocardiography was used to measure the left ventricular traditional Tei index (c-Tei) and tissue Doppler Tei index (t-Tei), left ventricular ejection fraction (LVEF) and other indicators. Results LVEDd, c-Tei and t-Tei in chronic heart failure group were significantly higher than those in normal control group (P <0.05), while LVEF was significantly lower in chronic heart failure group (P <0.05) (P <0.05). At 6 months, the cardiac function scores of c-Tei, t-Tei, LVEF, LVEDd and American New York Heart Association were significantly improved than those before treatment (P <0.05). Conclusion The application of Tei index in the evaluation of heart function in patients with heart failure is simple and feasible, c-Tei and t-Tei have the same effect.