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有人曾强调阿密替林和丙咪嗪对儿童有意外的严重中毒怍用。作者观察了60例因阿密替林与丙咪嗪中毒而住院的儿童。(男31例、女29例)。其中60%是应用这二药物治疗遗尿症引起中毒的。60例中3/4年龄为2—4岁。阿密替林中毒的患儿出现窦性心动过速、共济失调、幻觉和眼球震颤较多。丙咪嗪中毒以瞳孔扩大、发音困难、尿潴留和心律不整较常见。这些症状一般在用药4小时内发生。60例患儿的临床表现分为轻、中,重三组。轻度的35例,有嗜睡、不安、颜面潮红、幻觉、呕吐、瞳孔扩大和窦性心动过速。中度的22例,有共济失调、抽搐、发音困难、眼球震颤、反射亢进、巴彬斯基氏征阳性和收缩压增高。严重中毒的3例,临床特点为昏迷、抽搐、低血压、心电图异常和心脏、呼吸功能受阻抑。60例患儿中18例三环类抗抑郁剂
It has been emphasized that there are unintentional serious poisoning effects of amitriptyline and imipramine in children. The authors looked at 60 children hospitalized with amitriptyline and imipramine. (31 males and 29 females). 60% of them are caused by the use of these two drugs to treat enuresis. Three-fourths of 60 patients were 2-4 years old. Patients with amitriptyline have sinus tachycardia, ataxia, hallucinations, and nystagmus. Imipramine poisoning to dilated pupils, dysphonia, urinary retention and arrhythmia are more common. These symptoms usually occur within 4 hours of treatment. The clinical manifestations of 60 cases were divided into three groups: light, medium and heavy. Mild 35 cases, drowsiness, anxiety, facial flushing, hallucinations, vomiting, dilated pupils and sinus tachycardia. Moderate in 22 cases, ataxia, convulsions, dysarthria, nystagmus, hyperreflexia, Babinski’s sign positive and systolic blood pressure increased. Serious poisoning in 3 cases, clinical features of coma, convulsions, hypotension, abnormal ECG and heart, respiratory function suppressed. 18 cases of tricyclic antidepressants in 18 children