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目的考察参芝通络胶囊对大鼠的长期毒性,为临床用药提供依据。方法 SD大鼠随机分为对照组和参芝通络胶囊高、中、低剂量组(4、2、1g/kg)。ig给药13周,除观察一般状况外,检测体质量、血液学指标、血液生化指标,解剖计算内脏系数并进行病理组织学检查。剩余大鼠停止给药,恢复2周后进行上述相同指标检测。结果参芝通络胶囊各剂量组对大鼠一般状况、体质量、血液学指标、血液生化指标、内脏系数和病理组织学无明显影响,恢复期大鼠上述各指标与对照组比较无明显差异。结论在确定的临床使用剂量下,参芝通络胶囊长期服用无明显毒性。
Objective To investigate the long-term toxicity of Shenzhi Tongluo capsule to rats and provide the basis for clinical use. Methods SD rats were randomly divided into control group and Shenzhi Tongluo Capsule high, medium and low dose groups (4, 2, 1g / kg). ig administration for 13 weeks, in addition to observe the general condition, body mass testing, hematology, blood biochemical indicators, anatomical calculation of visceral coefficient and histopathological examination. The rest of the rats were stopped and the same index test as above was carried out after 2 weeks of recovery. Results The mice of Shenzhi Tongluo capsule had no significant effect on the general condition, body weight, hematology, blood biochemistry, visceral index and histopathology, while there was no significant difference between the rats in the recovery period and the control group . Conclusion In the determination of clinical dose, Shenzhi Tongluo Capsule long-term use without obvious toxicity.