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目的 :比较观察阿曲库铵和维库溴铵的量 效关系和恢复时相特征.方法 :选择 60例ASAⅠ级 ,年龄 17~5 0岁 ,施择期整形外科手术的患者 ,随机平均分成阿曲库铵组和维库溴铵组.用 60%N2 O O2 吸入辅以静注硫喷妥钠和芬太尼维持麻醉.用加速度仪监测神经肌肉功能.采用累计给药方法建立阿曲库铵和维库溴铵的量 效关系曲线.结果 :根据用最小二乘法建立的量 效关系曲线 ,阿曲库铵的作用强度仅为维库溴铵的 1/6.应用等效剂量的阿曲库铵和维库溴铵 (1 5*ED95)后 ,两药的高峰作用时间、临床肌松时间、恢复时间和体内作用时间无明显差别.结论 :阿曲库铵是一弱效能的中效非去极化肌松药 ,其神经肌肉阻滞强度仅为维库溴铵的 17%.“,”Objective :Tocomparethepharmacodynamiccharacteristicsofatracuriumwithvecuronium .Methods :Sixty patients,ASAgradeI,aged 17 5 0 years,scheduledforelectivesurgery .Thepatientswererandomlydividedintotwogroupsofatracuriumandvecuronium .Generalanesthesiawasmaintainedwith 60 %N2 Oinoxygen ,andi.v .incrementsofthiopental 2mg/kgorfentanyl 2 μg/kgasrequired .NeuromuscularfunctionwasassessedbyTOFstimulationofaccelerometryandthepercentagedepressionofT1responsewasusedasthestudyparameter .Thedose responserelationsofatracuriumandvecuroni umweredeterminedbythecumulativedose responsetechnique .Results:TakenfromED95,calculatedbylinearregression ,the ratioofpotencyatracuriumtovecuroniumwas 1∶6.Followingequipotentdosesoftwodrugs(1 5*ED95)wereused ,the time courseofrecoverywasnotsignificantlydifferentbetweenthetwodrugs .Conclusions:Atracuriumisalowpotencydepo larizingrelaxantwithintermediatedurationofactionanditsneuromuscularblockingpotencyisapproximately 17%ofvecuro niuminadultpatientsanesthetizedwithnitrousoxideandfentanyl.