论文部分内容阅读
目的 探讨血清组织多肽特异抗原 (TPS)水平与肺癌生物学行为的关系及其对肺癌的诊断价值。方法 采用酶联免疫吸附分析法 (ELISA)测定 69例肺癌患者及 2 0例作为对照的肺结核及肺炎患者血清TPS水平。结果 肺癌患者血清TPS水平 (2 73± 1 72 )U/L明显高于对照组患者[(1 1 5± 97)U/L ,P <0 0 0 1 ] ;52例发生转移的肺癌患者其血清TPS水平 (30 1± 1 2 7)U/L显著高于未转移者 [(1 83± 97)U/L ,P <0 0 1 ] ;TNM分期的Ⅲ期、Ⅳ期患者组TPS水平显著高于Ⅰ～Ⅱ期患者组(P <0 0 1 ,P <0 0 0 1 ) ;TPS与肺癌的组织分型有关 ,小细胞肺癌组患者TPS水平 (346± 1 63)U/L显著高于非小细胞肺癌组患者 [(2 4 8± 1 65)U/L ,P <0 0 5] ;1 6例接受化疗的肺癌患者化疗后TPS水平(1 78± 80 )U/L显著低于化疗前 [(2 52± 1 66)U/L ,P <0 0 5] ;TPS与癌胚抗原 (CEA) (P <0 0 1 )、神经元特异烯醇化酶 (NSE) (P <0 0 5)和组织多肽抗原 (TPA) (P <0 0 5)呈正相关 ,但与 1 9片段角质蛋白(CYFRA 2 1 1 ) (P >0 0 5)无明显相关。结论 血清TPS含量与肺癌临床分期、组织分型及转移密切相关 ,对肺癌的诊断具有较大的临床意义
Objective To investigate the relationship between the level of TPS in serum and the biological behavior of lung cancer and its diagnostic value in lung cancer. Methods Serum TPS level was measured in 69 patients with lung cancer and 20 patients with pulmonary tuberculosis and pneumonia by enzyme-linked immunosorbent assay (ELISA). Results The serum level of TPS (2 73 ± 1 72) U / L in lung cancer patients was significantly higher than that in the control group [(1 1 5 ± 97) U / L, P 0 001). In 52 lung cancer patients with metastasis Serum TPS levels (30 1 ± 1 2 7) U / L were significantly higher than those without metastasis [(1 83 ± 97) U / L, P 0 01; TNM stage Ⅲ, Ⅳ patients TPS levels (P <0.01, P <0.01). The TPS was correlated with the histological type of lung cancer. The level of TPS in small cell lung cancer group (346 ± 163) U / L was significantly higher than that in stage Ⅰ ~ Ⅱ patients Which was significantly higher than that of non-small cell lung cancer patients [(24.8 ± 165) U / L, P <0.05). The TPS level of 1 6 6 chemotherapy-treated lung cancer patients after chemotherapy was (1 78 ± 80) U / L (P <0.01), and the level of neuron-specific enolase (NSE) was significantly lower than that before chemotherapy [(522 ± 1 66) U / L, P <0.05) <0 05) and tissue polypeptide antigen (TPA) (P <0 05), but not with CYFRA 2 1 1 (P 0 05). Conclusion The serum TPS level is closely related to the clinical stage, histological type and metastasis of lung cancer, and has a great clinical significance for the diagnosis of lung cancer